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. Author manuscript; available in PMC: 2015 Oct 8.
Published in final edited form as: JAMA Psychiatry. 2014 Oct;71(10):1174–1182. doi: 10.1001/jamapsychiatry.2014.999

Figure 1. Interaction of ADRB2 Single-Nucleotide Polymorphism rs2400707 With Childhood Adversity in Adult Posttraumatic Stress Disorder.

Figure 1

Exposure to childhood adversity is coded 0 for no reported abuse (521 in the discovery cohort and 1370 in the replication cohort), 1 for 1 category reported (101 in the discovery cohort and 516 in the replication cohort), or 2 for 2 or more forms of child abuse reported (93 in the discovery cohort and 197 in the replication cohort). The PTSD Checklist (PCL) and PTSD Symptom Scale (PSS) scores are continuous measures of posttraumatic stress disorder. A, Discovery cohort (n = 715, P = 1.02 × 10−5 for interaction). B, Replication cohort (n = 2083, P = .0009 for interaction).