Table I.
Significant correlations between Biomarkers and: A – PBL Apoptotic biomarkers, B – Neutrophils, C – Inflammatory Indicator, D – Tocopherols and E – Transferrin saturation.
| Biomarker | Correlation | P-value | |
|---|---|---|---|
| A. PBL Apoptotic biomarkers | |||
| Caspase-9 | Bax | 0.45 | <0.001 |
| Caspase-8 | Bax | 0.47 | <0.001 |
| Nucleosomal DNA fragmentation | Bax | −0.37 | <0.001 |
| Caspase-3/7 | Bcl-2 | 0.075 | 0.010 |
| Caspase-9 | Bax/Bcl-2 ratio | 0.35 | 0.001 |
| Caspase-8 | Bax/Bcl-2 ratio | 0.38 | <0.001 |
| Nucleosomal DNA fragmentation | Bax/Bcl-2 ratio | −0.18 | 0.007 |
| B. Neutrophils | |||
| ANC | Bax/Bcl-2 ratio | 0.29 | 0.004 |
| ANC | Bcl-2 | −0.27 | 0.0035 |
| ANC | Bax | 0.21 | 0.045 |
| ANC | Nucleosomal DNA fragmentation | 0.19 | 0.04 |
| ANC | Caspase-9 | 0.16 | 0.048 |
| C. Inflammatory Indicator hsCRP | Nucleosomal DNA fragmentation | 0.25 | 0.01 |
| D. Tocopherols | |||
| α-tocopherol | Nucleosomal DNA fragmentation | 0.28 | 0.002 |
| γ-tocopherol | Caspase-3/7 | −0.23 | 0.02 |
| E. Transferrin saturation | Caspase-8 | −0.24 | 0.010 |
PBL, peripheral blood leucocyte; ANC, absolute neutrophil concentration; hsCRP, high sensitivity C-reactive protein; Note: alanine transaminase, aspartate transaminase, malondialdehyde, Vitamin C, non-transferrin bound iron, liver iron concentration, ferritin, γ-interferon, tumour necrosis factor-α, interleukin (IL)5 and IL8 did not correlate with PBL apoptotic markers.