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. 2015 Oct 8;10(10):e0138803. doi: 10.1371/journal.pone.0138803

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© 2015 Sisnande et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — a) Aminoacid sequence of the human and murine amylin. In bold are the different aminoacid. Notice the similarity in sequence from aminoacid 1 to 17. The N-terminus is the Lys1, which comprises the α- and ε-aminogroup, the two unique primary aminogroups in amylin targeted for PEGylation. b) Chemical structure of the methoxyl PEG N-hydroxylsuccinimide (NHS) carbonate. c) Structure of the human amylin. Human amylin (from NMR structure, PDB ID 2KB8) is represented in ribbons colored from aminoacid 1 (blue) to 37 (red). Notice the two aminogroups at the top left side of the representation.