Table 4. TNF-α inversely regulated differentiation genes.
| Gene Symbol | Gene Title | log2 ratio differentiation | log2 ratio TNF-α | Pathway association (differentiation) | Pathway association (TNF-α) | Literature background |
|---|---|---|---|---|---|---|
| Cpa1 | carboxypeptidase A1 | 3.56 | -1.57 | M | ||
| Aspn | asporin | 2.74 | -1.80 | Mothers against Dpp homolog, TGFβ | SkM | |
| Adamts5 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) | 2.66 | -1.28 | TGFβ | Matrix metallo proteinase | SkMDiff |
| Fibin | fin bud initiation factor homolog (zebrafish) | 2.65 | -1.10 | SkM | ||
| Trdn | triadin | 2.45 | -1.05 | Ryanodine receptor | SkMDiff | |
| Slc40a1 | solute carrier family 40 (iron-regulated transporter), member 1 | 2.34 | -1.85 | Tumor necrosis factor (TNF superfamily member 2) | SkM | |
| Capn6 | calpain 6 | 2.20 | -2.21 | NF kappa B | SkMDiff | |
| Nrk | Nik related kinase | 2.06 | -1.25 | SkM | ||
| Cmbl | carboxymethylenebutenolidase-like (Pseudomonas) | 2.04 | -1.36 | new | ||
| Aknad1 | AKNA domain containing 1 | 2.03 | -1.32 | new | ||
| Parm1 | prostate androgen-regulated mucin-like protein 1 | 2.00 | -1.69 | M | ||
| Itm2a | integral membrane protein 2A | 1.99 | -1.68 | SkMDiff | ||
| Sepp1 | selenoprotein P, plasma, 1 | 1.87 | -1.06 | new | ||
| Ndst4 | N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4 | 1.73 | -1.29 | new | ||
| Tecrl | trans-2,3-enoyl-CoA reductase-like | 1.66 | -1.40 | new | ||
| Cnr1 | cannabinoid receptor 1 (brain) | 1.64 | -1.03 | SkMDiff | ||
| Unc13c | unc-13 homolog C (C. elegans) | 1.62 | -1.71 | new | ||
| Spats2l | spermatogenesis associated, serine-rich 2-like | 1.51 | -1.07 | new | ||
| Mybpc1 | myosin binding protein C, slow-type | 1.34 | -1.03 | SkM | ||
| Lix1 | limb expression 1 homolog (chicken) | 1.16 | -1.42 | new | ||
| Csdc2 | cold shock domain containing C2, RNA binding | 1.15 | -1.19 | new | ||
| Fzd4 | frizzled homolog 4 (Drosophila) | 1.04 | -1.26 | SkMDiff | ||
| Serpinb2 | serine (or cysteine) peptidase inhibitor, clade B, member 2 | -2.28 | 1.74 | Tumor necrosis factor (TNF superfamily member 2) | M |
List of genes upregulated by differentiation but downregulated because of TNF-α treatment or vice versa. Log2 ratios indicate the order of magnitude of differential expression. Enriched signal transduction pathway associations in which the respective gene is involved during differentiation or TNF-α treatment are shown. The literature background indicates whether the gene has been published in skeletal muscle differentiation (SkMDiff), skeletal muscle (SkM), heart muscle, smooth muscle, or muscle progenitor cells (M), or whether it has not been described in muscle (new).