Table 1. Proportion of rodents experimentally inoculated with high or low dose L. braziliensis that showed signs of established infection defined as presentation of skin lesions, spenomegaly at necropsy, detection of Leishmania in tissue samples, or/and xenopositivity.
| Experimental inoculation | Leishmania detected in tissues 1 | Presence of skin lesions | Spleno-megaly at necropsy | Infectious to sand flies 2 | animals infected/ inoculated 3 |
|---|---|---|---|---|---|
| High dose | |||||
| Necromys lasiurus | 7/8 | 8*/8 | 3/8 | 8/8 | 8/8 |
| Nectomys squamipes | 6/8 | 3/8 | 0/8 | 1/8 | 8/8 |
| Rattus rattus | 4/10 | 2/10 | 0/10 | 0/9 | 3/10 |
| subtotal | 14/26 | 13/26 | 3/26 | 9/25 | 19/26 |
| Low dose | |||||
| Necromys lasiurus | 9/10 | 0/10 | 1/10 | 10/10 | 10/10 |
| Nectomys squamipes | 10/10 | 0/10 | 2/10 | 9/10 | 10/10 |
| Rattus rattus | 2/9 | 1*/9 | 0/9 | 6/9 | 6/9 |
| subtotal | 21/29 | 1/29 | 3/29 | 25/29 | 26/29 |
1 Ear skin, liver and spleen tissue samples screened for Leishmania by qPCR.
2 Infectiousness defined as infecting ≥1 dissected sand fly by xenodiagnosis.
3 Total number of experimentally inoculated animals that survived to follow-up
* Metastatic lesions at base of tail—7 N.lasiurus (4 had ear lesion) and 1 R.rattus.