Table 3. L. braziliensis parasite loads 1 detected in tissue samples from rodents with infections established by high or low dose initial inoculum.
Rodent/dose | Tissue sample | Pos/N tested | mean | Median (IQR) 2 | range |
---|---|---|---|---|---|
High dose | |||||
N. lasiurus | skin | 8/8 | 3.6×102 | 52 (2–1006) | 1–1.6×103 |
spleen | 6/8 | 3.9×102 | 2 (0–1110) | 0–2.8×103 | |
liver | 7/7 | 1.4×102 | 6 (6–632) | 1–8.9×102 | |
N. squamipes | skin | 7/7 | 1.5×103 | 56 (10–6263) | 6–8.1×103 |
Spleen | 6/6 | 3.2×102 | 11 (8–1641) | 1.8×103 | |
liver | 7/7 | 1.6×102 | 9 (3–668) | 3–8.8×102 | |
R. rattus | skin | 1/9 | 0.3 | 0 (0–0) | 0–3 |
spleen | 1/9 | 2.6 | 0 (0–0) | 0–2.3×101 | |
liver | 0/8 | 0 | 0 (0–0) | 0–0 | |
Low dose | |||||
N. lasiurus | skin | 8/9 | 1.3×101 | 8 (5–17) | 0–4.6×101 |
spleen | 9/9 | 3.4×101 | 2 (2–5) | 1–2.9×102 | |
liver | 9/9 | 2.4×101 | 6 (2–51 | 1–1.3×102 | |
N. squamipes | skin | 9/10 | 3.7×101 | 14 (5–43) | 0–2.3×102 |
spleen | 10/10 | 4.4×101 | 25 (9–61) | 4–2.0×102 | |
liver | 10/10 | 9.0×101 | 10 (4–127) | 4–6.4×102 | |
R. rattus | skin | 1/8 | 0.9 | 0 (0–2) | 0–7 |
spleen | 1/9 | 0.1 | 0 (0–0) | 0–1 | |
liver | 2/8 | 4.3 | 0 (0–17) | 0–1.8×101 |
1 Leishmania copy numbers (loads) measured by qPCR were standardized to the number of host gene GAPDH copies.
2 IQR interquartile range