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. 2015 Oct 8;10(10):e0140168. doi: 10.1371/journal.pone.0140168

Fig 3. HSPA1 methylation status is associated with survival in HGSC.

Fig 3

(A) Kaplan-Meier survival curve showing the association between levels of the unmethylated form of Lys561 on HSPA1 in effusions and overall survival (OS) for 53 HGSC patients. Patients with effusions with higher-than-median relative abundance of me0 (Me0 high; n = 25, dashed green line) had a mean OS of 22 months vs. 61 months for patients whose effusions showed lower-than-or-equal-to-median relative abundance of me0 (Me0 low; n = 28, solid blue line; p = 0.015). “+” indicates patients who were alive at the end of their follow-up period, and therefore were censored. (B) Kaplan-Meier survival curve showing the association between levels of the unmethylated form of Lys561 on HSPA1 in effusions and progression-free survival (PFS) for 53 HGSC patients. Patients with effusions with higher-than-median relative abundance of me0 (Me0 high; n = 25, dashed green line) had a mean PFS of 3 months vs. 26 months for patients whose effusions showed lower-than-or-equal-to-median relative abundance of me0 (Me0 low; n = 28, solid blue line; p = 0.012). “+” indicates one patient who was alive without signs of disease at the end of the follow-up period, and was, therefore, censored.