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. Author manuscript; available in PMC: 2015 Oct 8.
Published in final edited form as: Biomaterials. 2011 Mar 22;32(19):4450–4463. doi: 10.1016/j.biomaterials.2011.02.059

Fig. 2.

Fig. 2

HPMA copolymer-ALN-TNP-470 conjugate does not cause body weight loss nor affects the neurological function of non-tumor bearing mice. (A) Treatment with free combination of ALN plus TNP-470 (open triangles) hindered weight gain in mice, whereas HPMA copolymer-ALN-TNP-470 conjugate (closed triangles) did not affect body weights similar to control mice (open circles). (B) Mice treated with HPMA copolymer-ALN-TNP-470 conjugate remained on the rotarod similar time as the control group, whereas mice treated with free combination of ALN plus TNP-470 remained significantly shorter period of times. Data represent mean ± s.e.m.