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Immunoblotting and corresponding quantification of fibroblast protein lysates with antibodies against pERK, pAKT and pS6RP and their respective total proteins, derived from Q510E mutant and wild type (WT) fibroblasts under baseline conditions, demonstrating that Q510E mutant cells have elevated AKT/mTOR signaling at baseline. n=4-5 independent experiments. Data represent the mean ± SEM; p values were derived using 2-tailed Student’s t test. * p<0.05 ; ns=non-signifiant.
