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. Author manuscript; available in PMC: 2015 Oct 8.
Published in final edited form as: Ann Hematol. 2015 Mar 27;94(0 2):S249–S257. doi: 10.1007/s00277-015-2319-x

Table 1.

Comparative results from frontline randomized clinical trials of imatinib 400 mg/day vs. second-generation TKIs for newly diagnosed CML in chronic phase

Daily dose (mg) Still on study therapy (years) PFS (years) OS (years) MMR (years) Median age, years (range) Male (%)
Imatinib 400 50 (5) 91 (5) 92 (5) 60 (5) 46 (18–80) 56
69 (3) 91 (3) 93 (3) 55 (3) 49 (18–78) 63
72 (1) 90 (3) 97 (3) 44 (1) 50 (19–89) 59
80 (1) 93 (1)a 97 (1) 32 (1) 47 (18–89) 54
73 (3.5) 94 (3) 95 (3) 79 (3) 54 (16–88) 60
NR 80 (4) 90 (4) 36 (1) 50 (23–80) 63
Nilotinib 300 BID 60 (5) 92 (5) 94 (5) 77 (5) 47 (18–85) 56
Dasatinib 100 71 (3) 91 (3) 94 (3) 69 (3) 46 (18–84) 56
80 (1) 93 (3) 97 (3) 59 (1) 47 (18–90) 60
Bosutinib 500 71 (1) 94 (1)a 99 (1) 47 (1) 48 (19–91) 60

Data collected from references [18] (references for frontline clinical trials in chronic phase CML)

PFS progression-free survival, OS overall survival, MMR major molecular response, NR not reported

a

Event-free survival