Skip to main content
. 2015 Oct 7;66(4):332–337. doi: 10.1097/FJC.0000000000000283

FIGURE 5.

FIGURE 5

Superior pharmacological effect of macitentan on top of ambrisentan in conscious Dahl-S rats. Although addition of ambrisentan 30 mg/kg on top of ambrisentan 30 mg/kg did not induce further MAP reduction, confirming that a plateau of effect had been reached with ambrisentan (A), addition of macitentan 30 mg/kg on top of ambrisentan 30 mg/kg further decreased blood pressure by 17 mm Hg, *P < 0.05 versus vehicle (B). Conversely, addition of ambrisentan 30 mg/kg on top of macitentan 30 mg/kg did not induce further blood pressure reduction (C) (n = 6 per group).