Table 1. Clinical characteristics of the acromegaly (Acro) and the non-functioning pituitary adenoma (NFPA) group.
| Acro (n = 46) | NFPA (n = 20) | P | |
|---|---|---|---|
| Sex (male/female) | 11/35 | 8/12 | 0.16 |
| Age (years) | 50.9 ± 12.0 | 56.2 ± 12.2 | 0.12 |
| BMI | 25.7 ± 3.0 | 25.3 ± 2.1 | 0.83 |
| Smoking (%) | 15.2 | 25.0 | 0.41 |
| Diabetes (%) | 19.4 | 7.8 | 0.33 |
| HbA1c (%) | 5.9 ± 0.77 | 5.4 ± 0.52 | 0.59 |
| Hypertension (%) | 34.2 | 38.5 | 0.78 |
| Dyslipidemia (%) | 26.8 | 35.3 | 0.52 |
| Macroadenoma (%) | 74.7 | 100 | 0.11 |
| Tumor diameter (mm) | 14.1 ± 5.7 | 24.8 ± 6.5 | < 0.01** |
| Random GH (ng/mL) | 12.1 [13.3] | 0.2 [0.5] | < 0.01** |
| IGF-I SDS | 6.6 ± 2.7 | −0.2 ± 1.5 | < 0.01** |
| PRL (ng/mL) | 12.6 [13.8] | 14.5 [16.1] | 0.99 |
| ACTH (pg/mL) | 32.2 [20.8] | 30.0 [25.1] | 0.88 |
| Cortisol (μg/dL) | 12.6 ± 3.3 | 13.0 ± 3.5 | 0.68 |
| TSH (μU/mL) | 0.90 ± 0.55 | 1.25 ± 0.67 | 0.06 |
| FT4 (ng/mL) | 0.99 ± 0.22 | 0.96 ± 0.12 | 0.59 |
| LH male (IU/mL) | 2.1 [1.1] | 3.1 [4.2] | 0.29 |
| LH female (IU/mL) | 10.4 [11.7] | 3.0 [10.7] | 0.08 |
| FSH male (IU/mL) | 7.3 [7.3] | 12.9 [8.8] | 0.08 |
| FSH female (IU/mL) | 42.9 [55.1] | 15.8 [36.2] | 0.37 |
| E2 (pg/mL) | 7.1 [37.2] | 0 [0] | 0.12 |
| T (ng/mL) | 213.3 ± 78.2 | 280.8 ± 99.1 | 0.20 |
Data were compared by the χ2 test, Fischer’s exact test, Student’s t-test, or Mann—Whitney test, as appropriate.
**P < 0.01.
RTL, relative telomere length; Acro, acromegaly; NFPA, non-functioning pituitary adenoma; E2, estradiol; T, testosterone. E2 and T were measured in female and male, respectively.