Table 3. Serum biomarkers of DM-IP on admission in patients with RPIP and CIP.
| Variables | RPIP (n = 14) | CIP (n = 7) | P |
|---|---|---|---|
| Positive anti-MDA5-Ab, n (%) | 7 (50) | 1 (14) | 0.17 |
| Positive anti-ARS-Ab, n (%) | 6 (43) | 3 (43) | 1 |
| CK, IU/l | 287 (17–5330) | 103 (77–6049) | 0.91 |
| LD, IU/l | 416 (230–782) | 253 (180–894) | 0.23 |
| CRP, mg/dl | 1.95 (0.29–12.8) | 0.14 (0.04–0.63) | 0.0004* |
| KL–6, U/ml | 1255.5 (425–3898) | 1017 (423–2015) | 0.22 |
| Ferritin, ng/ml | 1073.5 (28–23272.5) | 97.6 (46.7–247.1) | 0.28 |
| LIGHT, pg/ml | 156 (49.6–335.4) | 94.3 (16–164.2) | 0.02* |
| IL–6, pg/ml | 18.5 (4.5–154.5) a | 2.4 (0.6–7.9) b | 0.08 |
Laboratory markers are presented as the median (interquartile range). DM: dermatomyositis; IP: interstitial pneumonia; RPIP: rapid progressive IP; CIP: chronic IP; MDA5: anti-melanoma differentiation-associated gene 5; Ab: antibody; ARS: aminoacyl-tRNA synthetase; CK: creatine kinase; LD: lactate dehydrogenase; CRP: C-reactive protein; IL–6: interleukin 6. The P-values were estimated using Fisher’s exact test or Mann-Whitney U-test.
*P <0.05.
an = 10.
bn = 5.