Table 4. Serum biomarkers of DM-IP on admission in patients dead due to IP and those still alive.
| Variables | Dead (n = 4) | Alive (n = 16) | P |
|---|---|---|---|
| Positive anti-MDA5ab, n (%) | 4 (100) | 4 (25) | 0.01* |
| Positive anti-ARSab, n (%) | 0 (0) | 8 (50) | 0.12 |
| CK, IU/l | 105 (43–287) | 174.5 (17–6049) | 0.37 |
| LD, IU/l | 349 (312–485) | 310 (180–894) | 0.76 |
| CRP, mg/dl | 1.30 (0.91–2.85) | 0.7 (0.04–8.27) | 0.42 |
| KL–6, U/ml | 1808 (501–3898) | 1074 (423–3006) | 0.29 |
| Ferritin, ng/ml | 1330.3 (477.7–1611) | 141.9 (28–23272.5) | 0.79 |
| LIGHT, pg/ml | 154.7 (65.3–335.4) | 115.9 (16–261.3) | 0.34 |
| IL–6, pg/ml | 22.7 (20.4–154.5) a | 7.9 (0.6–86.6) b | 0.13 |
Laboratory markers are presented as the median (interquartile range). DM, dermatomyositis; IP, interstitial pneumonia; Dead, dead due to IP; MDA5, anti-melanoma differentiation-associated gene 5; Ab, antibody; ARS, aminoacyl-tRNA synthetase; CK, creatine kinase; LD, lactate dehydrogenase; CRP, C-reactive protein; IL–6, interleukin 6. The P-values were estimated using Fisher’s exact test or Mann-Whitney U-test.
*P <0.05.
an = 3.
bn = 11.