Skip to main content
. 2015 Oct 8;10(10):e0139699. doi: 10.1371/journal.pone.0139699

Fig 7. NEET proteins provide a link between the ISC and CIA pathways.

Fig 7

mNT on the OMM and NAF-1 on the MAM receive 2Fe-2S clusters produced inside the mitochondria by the ISC system. Both mNT and NAF-1 transfer these 2Fe-2S clusters to Anamorsin. Anamorsin receives electrons from the diflavin reductase NDOR1 and supplies them to the CIA system as an early step necessary for the production of 4Fe-4S clusters. This step requires the holo form of Anamorsin. Both mNT and NAF-1 can provide parallel routes linking CIA to ISC. CIA produced clusters are targeted to proteins in the cytosol and the nucleus and are important for cell metabolism, maintenance and proliferation.