Figure 3.

In vivo distribution and tumor growth delay of Nufs-DTX.

Notes: (A) Tissue distribution of Nufs-DTX after intravenous injection. Unlike Taxotere™ that was accumulated mainly in the lungs after intravenous administration, Nufs-DTX was observed mainly in the liver. Taxotere™ was detected in the main organs including the lungs, liver, spleen, and kidneys over the collecting time points (hour), while Nufs-DTX was well cleared from each organ. (B) In serum, both the drugs showed similar pattern in distribution and clearance over a period of time. In tumors, a relatively large amount of accumulated Nufs-DTX was observed compared with Taxotere™. (C) Tumor growth delay after injecting three times every other day. Nufs-DTX showed effective tumor growth delay compared with other controls, including Taxotere™-treated group. Arrows indicate time of injections.

Abbreviations: DTX, docetaxel; Nufs, nanoparticulation using fat and supercritical fluid.