Skip to main content
. 2015 Oct 1;8:483–493. doi: 10.2147/DMSO.S54953

Table 2.

Efficacy of insulin degludec 100 U/mL versus glargine insulin on HbA1c and fasting blood glucose in patients with type 2 diabetes mellitus

Study Arm HbA1c (% ± SD) HbA1c reduction (% ± SD) ETD (%) for HbA1c reduction (CI 95%) FBG (mmol/L±SD) FBG reduction (mmol/L) ETD (mmol/L) for FPG [CI 95%]
BEGIN Once Long13 IDeg (n=773) 7.1 −1.06 (±1.01) 0.09 [−0.04, 0.22] 5.9 −3.8±3.04 −0.43 [−0.74, −0.13]
IGla (n=257) 7.0 −1.19 (±0.97) P = NA 6.4 −3.3±2.87 P=0.005
BEGIN Once Long (extension)14 IDeg (n=773) 7.0±0.9 NA 0.07 [−0.07, 0.22] 5.56±1.82 −4.17 −0.36 [−0.67, −0.05]
IGla (n=257) 6.9±0.8 NA P=0.339 5.93±1.69 −3.56 P=0.021
BEGIN Once Asia15 IDeg (n=289) 7.2 −1.24 0.11 [−0.03, 0.24] 5.5 2.88 −0.09a [−0.41, 0.23]
IGla (n=146) 7.1 −1.35 P = NA 5.7 2.97 P=0.59
BEGIN Basal-Bolus Type 216 IDeg (n=744) NA −1.10 NA −2.3 −0.29 [−0.65, 0.06]
IGla (n=248) NA −1.18 0.08 [−0.05, 0.21]
P = NA
NA −2.0 P=0.1075
IDeg (n=226) NA −1.07 IDegForced-Flex versus
IDeg NA
5.8 NA IDegForced-Flex versus
IDeg
−0.05 [0.45, 0.25]
P = NA
BEGIN Flex T217 IDegForced-Flex (n=230) NA −1.28 IDegForced-Flex versus
IGla
0.04 [−0.12, 0.20]
5.8 NA IDegForced-Flex versus
IGla
−0.42 [−0.82, −0.02]
IGla (n=229) NA −1.26 6.2 NA P=0.04

Note:

a

ETD (mmol/L) for FPG in favor of IGla, mean ± SD.

Abbreviations: CI, confidence interval; ETD, estimated treatment difference; FPG, fasting plasma glucose; IDeg, insulin degludec; IDegForced-Flex, insulin degludec with forced flexible scheme; IDet, detemir insulin; IGla, glargine insulin; NA, not available; SD, standard deviation.