Table 3.
Mutations associated with resistance to MVC
| Mutations | HIV region | Specimens |
|---|---|---|
| Mutations found in clinical specimens | ||
| G11R110 | V3 of gp120 | Plasma |
| P13R110 | V3 of gp120 | Plasma |
| A25K110 | V3 of gp120 | Plasma |
| A316T112,118 | V3 of gp120 | Primary clinical isolates and plasma |
| P/T308H116 | V3 of gp120 | Plasma |
| T320H116 | V3 of gp120 | Plasma |
| I322aV116 | V3 of gp120 | Plasma |
| D407G116 | V4 of gp120 | Plasma |
| V489I116 | C5 of gp120 | Plasma |
| I20F + Y21I110 | V3 of gp120 | Plasma |
| Mutations found in vitro | ||
| A319S112 | V3 of gp120 | Primary clinical isolates |
| V169M113 | V2 of gp120 | HIV strain CC1/85 |
| N192K113 | V2 of gp120 | HIV strain CC1/85 |
| L317W113 | V3 of gp120 | HIV strain CC1/85 |
| I408A113 | V4 of gp120 | HIV strain CC1/85 |
| D462N113 | V5 of gp120 | HIV strain CC1/85 |
| N463T113 | V5 of gp120 | HIV strain CC1/85 |
| S464T113 | V5 of gp120 | HIV strain CC1/85 |
| N465aD113 | V5 of gp120 | HIV strain CC1/85 |
| L820I113 | gp41 | HIV strain CC1/85 |
| I829V113 | gp41 | HIV strain CC1/85 |
| Y837C113 | gp41 | HIV strain CC1/85 |
| T199K/T275M114 | C2 of gp120 | HIV-1JR-FL-P17 and/or HIV-1V3Lib-P17 |
| T275M114 | C2 of gp120 | HIV-1JR-FL-P17 and/or HIV-1V3Lib-P17 |
| I304V114 | V3 of gp120 | HIV-1JR-FL-P17 and/or HIV-1V3Lib-P17 |
| F312W114 | V3 of gp120 | HIV-1JR-FL-P17 and/or HIV-1V3Lib-P17 |
| T314A114 | V3 of gp120 | HIV-1JR-FL-P17 and/or HIV-1V3Lib-P17 |
| E317D114 | V3 of gp120 | HIV-1JR-FL-P17 and/or HIV-1V3Lib-P17 |
Abbreviation: MVC, maraviroc.