Table 1.

List of pharmacokinetic parameters derived by fitting the conventional two-compartment model to the plasma data

Parameter	Unit	Gen-MEs	Gen-micelles	Gen solution
k10	1/h	3.22±1.27**	4.61±1.54**	7.68±2.32
t1/2α	h	0.10±0.04	0.11±0.03	0.07±0.03
t1/2β	h	9.96±3.27**	7.5±3.39*	2.15±2.35
CL	L/h	1.28±0.37**	1.33±0.36**	2.57±0.43
CL2	L/h	0.73±0.21**,##	1.53±0.15**	2.94±0.29
AUC0−t	µM*h	8.48±1.33**,##	5.55±0.59**	2.97±0.73
AUC0−inf	µM*h	9.44±1.93**,#	6.52±1.53**	3.99±0.77
AUMC	µM*h2	38.27±5.21**,##	27.93±3.99**	5.14±1.63
MRT	h	8.27±1.28**,#	5.27±1.56**	1.12±1.26
Vss	L	6.98±1.51**	7.03±3.11*	2.52±2.41

Notes: Student’s t-test,

^*P<0.05,

^**P<0.01, compared with Gen solution;

^#P<0.05,

^##P<0.01, compared with Gen-micelles. Data are presented as mean ± standard deviation.

Abbreviations: Gen, genistein; Gen-MEs, Gen-loaded micellar emulsions; h, hour; k₁₀, elimination rate constant from the central compartment; t_1/2α, redistribution half-life; t_1/2β, elimination half-life; CL, clearance of central compartment; CL₂, clearance of peripheral compartment; AUC, area under the plasma concentration–time curve; AUMC, area under the first moment of the plasma concentration–time curve; MRT, mean retention time; V_ss, steady-state volume of distribution.