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. 2015 Sep 30;10:6075–6087. doi: 10.2147/IJN.S90887

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© 2015 Liu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Roles played by MAPK subfamilies in the mitochondrial apoptosis induced by three rod-like gold-mesoporous silica nanoparticles.

Notes: MCF-7 cells were separately treated with 12.5 µg/mL of three rod-like gold-mesoporous silica nanoparticles for 24 hours; then, whole-cell lysates were collected and immunoblotted using antibodies against MAPK subfamily proteins, such as ERK, p-ERK, p38, p-p38, JNK, and p-JNK (A), as well as apoptosis-related proteins, such as cyt c, Bcl-2, Bax, caspase-9, caspase-3, and PARP (B). GAPDH was used as a standard to ensure the equal loading of lysates. (C) Quantitative analysis of the ratio of Bax/Bcl-2. Values are presented as means ± SD of three determinations. *P<0.05 versus control group.

Abbreviations: Au, gold; MAPK, mitogen-activated protein kinase; ERK, extracellular-signal-regulating kinase; JNK, c-Jun-N-terminal kinase; cyt c, cytochrome c; Bcl-2, B-cell lymphoma-2; Bax, Bcl-2-associated X protein; PARP, polyADP-ribose polymerase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; SD, standard deviation.