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. 2015 Sep 30;10:6075–6087. doi: 10.2147/IJN.S90887

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© 2015 Liu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The effect of JNK on the mitochondrial apoptosis induced by three rod-like gold-mesoporous silica nanoparticles.

Notes: MCF-7 cells were separately treated with 12.5 µg/mL of three rod-like gold-mesoporous silica nanoparticles for 24 hours in the presence or absence of 30 µM SP600125. (A) Cytotoxicity was analyzed using an MTT assay. (B) Then, the apoptotic ratio was assessed based on Annexin V-FITC/PI binding and measured using flow cytometry. (C) The expression of p-JNK and cleaved caspase-3 was analyzed using western blotting. The data represent three separate experiments. Mean values ± SD. *P<0.05 versus a control group, **P<0.01 versus a control group.

Abbreviations: Au, gold; FITC, fluorescein isothiocyanate; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; PI, propidium iodide; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; SP600125, 1,9-pyrazoloanthrone; JNK, c-Jun-N-terminal kinase; SD, standard deviation.