Table 3.
Dolutegravir adverse effects grades 2–4 in treatment-naïve trials
| Side effects | Range (%) | Comments |
|---|---|---|
| Gastrointestinal | 2–17 | Diarrhea and nausea were the most common GI side effects, mainly mild-to-moderate in severity |
| Headache | 1–15 | Mainly mild in nature |
| Insomnia | 1–4 | Were typically mild in intensity |
| Rash | 1 | Were significantly low in most of the studies (generalized macular rash, maculopapular rash, pruritic rash) |
| Liver abnormality | 2–3 | Alternative causes for raised ALT identified in few patients. Very few patients had DTG-associated DILI with hypersensitivity reaction |
| Nasopharyngitis | <1 | Mild in nature |