Figure 1.

Multivariate analysis of factors affecting overall survival, progression-free survival and duration of treatment. Factors were sorted by HR (in univariate analysis) for OS. Error bars indicate lower and upper confidence intervals, and symbols indicate point estimates. Only the values in the model optimized by stepwise method are shown because values do not exist for non-significant factors. Factors that were used in the multivariate analysis, but were not significant for any parameters were not shown for clarity. They include body weight, bone metastasis, ALT, creatinine, renal comorbidity, cardiac comorbidity and starting dose. The median value was used as the cutoff value for laboratory test values. ECOG PS, Eastern Cooperative Oncology Group performance status; AST, aspartate aminotransferase; IFN-α, interferon-alfa; OS, overall survival; HR, hazard ratio; PFS, progression-free survival; DOT, duration of treatment; ALT, alanine aminotransferase.