TABLE 3.
Multivanate analysis of factors associated with receipt of CPM versus other types of surgery
| Among all women (n = 560) |
Among women where BCS was an option or was recommended (n = 367) |
|||
|---|---|---|---|---|
| CPM versus UM | CPM versus BCS | CPM versus UM | CPM versus BCS | |
| OR (95 % CI) | OR (95 % CI) | OR (95 % CI) | OR (95 % CI) | |
| Age at diagnosis (year) | 0.97 (0.91–1.04) | 0.99 (0.93–1.06) | 0.99 (0.90–1.09) | 1.00 (0.93–1.08) |
| Married/living as married (ref = unmarried) | 0.96 (0.50–1.83) | 1.30 (0.71–2.36) | 0.87 (0.34–2.23) | 1.58 (0.76–3.28) |
| Parous (ref = nulliparous) | 1.39 (0.78–2.50) | 2.17 (1.23–3.83)* | 1.77 (0.76–4.14) | 2.16 (1.08–4.33)¥ |
| BMI (kg/m2) | 0.96 (0.92–1.01) | 0.93 (0.89–0.97)* | 0.92 (0.85–0.99)¥ | 0.91 (0.86–0.97)* |
| T2 tumor size or greater (ref = T1) | 0.88 (0.53–1.46) | 2.03 (1.22–3.38)* | 0.95 (0.46–1.96) | 2.37 (1.28–4.37)* |
| Any nodal involvement (ref = N0) | 0.71 (0.43–1.16) | 1.82 (1.08–3.06)¥ | 0.43 (0.21–0.89)¥ | 0.98 (0.51–1.89) |
| Her2 positivity (ref = Her2 negative) | 0.86 (0.53–1.41) | 1.82 (1.08–3.08)¥ | 0.61 (0.30–1.25) | 1.39 (0.73–2.65) |
| BRCA testing (ref = tested/BRCA negative) | ||||
| Tested/BRCA+ | 12.63 (3.59–44.48)* | 10.30 (3.77–28.18)* | 28.63 (3.32–246.48)* | 13.09 (4.32–39.61)* |
| Not tested/unknown | 0.38 (0.18–0.83)¥ | 0.47 (0.21–1.06) | 0.39 (0.11–1.36) | 0.49 (0.16–1.51) |
| First-degree relative w/breast or ovarian cancer (ref = negative first-degree family history) | 1.72 (0.85–3.45) | 1.68 (0.86–3.25) | 2.45 (0.80–7.49) | 1.69 (0.78–3.68) |
| Anxiety (ref = HADS <8) | ||||
| HADS 8–10 | 2.13 (1.14–3.98)¥ | 2.84 (1.51–5.31)* | 2.97 (1.19–7.39)¥ | 3.46 (1.63–7.35)* |
| HADS ≥11 | 2.04 (1.00–4.16)¥ | 2.23 (1.11–4.51)¥ | 4.88 (1.62–14.65)* | 3.34 (1.40–7.97)* |
| Depression (ref = HADS <8) | ||||
| HADS 8–10 | 1.33 (0.66–2.71) | 1.52 (0.74–3.11) | 0.76 (0.27–2.13) | 1.14 (0.47–2.75) |
| HADS ≥11 | 1.93 (0.68–5.49) | 1.74 (0.63–4.84) | 3.01 (0.43–21.04) | 1.30 (0.36–4.79) |
| Fear of recurrence (ref = moderate/low concern) | 0.56 (0.32–0.98)¥ | 0.49 (0.28–0.86)¥ | 0.28 (0.12–0.65)* | 0.35 (0.17–0.71)* |
| Decisional involvement (ref = shared) | ||||
| Mainly patient's decision | 3.23 (1.98–5.27)* | 2.78 (1.72–4.50)* | 1.89 (0.94–3.79) | 3.09 (1.75–5.46)* |
| Mainly doctor's decision | 0.09 (0.02–0.37)* | 0.08 (0.02–0.32)* | 0.32 (0.04–2.68) | 0.09 (0.01–0.56)* |
| Very/extremely high confidence with decision (ref = low/moderate confidence) | 2.60 (0.78–8.71) | 5.20 (1.72–15.73)* | 4.27 (0.92–19.75) | 3.89 (0.98–15.50) |
CPM contralateral prophylactic mastectomy, UM unilateral mastectomy, BCS breast-conserving surgery, HADS Hospital Anxiety and Depression Scale, ref reference category
*
p ≤ 0.01
¥
p ≤ 0.05