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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Nat Med. 2015 Sep 21;21(10):1146–1153. doi: 10.1038/nm.3939

Figure 2.

Figure 2

Upstream regulators of Baz1a. (a) Baz1a mRNA levels after exposure to KCl or BDNF in primary mouse striatal neurons. n = 3 per group. (b) NAc Baz1a mRNA levels 48 hours after 10 days of 5–minute daily VTA channelrhodopsin (ChR2) optogenetic stimulations in control mice. Control n = 8 and ChR2 n=18. (c) Paradigm for the experiment is shown in top panel. Bottom panel shows that optogenetic stimulation increased susceptibility to social defeat stress. n = 8 per group. (d) NAc Baz1a mRNA levels after local BDNF infusion in mice. Control n = 8, BDNF n = 9. For a–d, Post–hoc Student’s t–test * P < 0.05, ** P < 0.01 compared to respective controls. See Supplementary Information for detailed statistics.