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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Nat Med. 2015 Sep 21;21(10):1146–1153. doi: 10.1038/nm.3939

Figure 3.

Figure 3

ACF complex in NAc mediates stress susceptibility. Experimental schematics for each experiment are included above. (a) ACF complex (BAZ1A + SMARCA5) overexpression in NAc decreased social interaction (SI) and sucrose preference (SP) after subthreshold (micro–) defeat. GFP n = 9; BAZ1A n = 9; SMARCA5 n = 9; BAZ1A + SMARCA5 n = 7. (b) ACF complex overexpression in NAc decreased SI, time in open arm of elevated plus maze (EPM), and SP after four–day defeat paradigm. GFP n = 7; BAZ1A + SMARCA5 n = 10. (c) BAZ1A knockdown in NAc increased SI and SP after CSDS, with a trend for increased time in open arm of EPM. GFP n = 10; BAZ1A miR n = 9. (d) Overexpression of ACF complex in NAc of resilient mice after CSDS. GFP n = 7; BAZ1A + SMARCA5 n = 7. (e) ACF1 knockdown in susceptible mice after CSDS. GFP n = 8; BAZ1A miR n = 8. For a–e, post–hoc Student’s t–test # 0.05 < P <0.1; * P < 0.05; ** P < 0.01; *** P < 0.001. See Supplementary Information for detailed statistics.