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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Nat Med. 2015 Sep 7;21(10):1223–1227. doi: 10.1038/nm.3937

Figure 3.

Figure 3

Penetration of RIF in TB lesions. (a) Ion maps of RIF in lung lesions collected following a single drug dose; (b) RIF accumulates in necrotic foci at steady-state. H&E staining of adjacent sections are shown below each set of ion maps. Black/white contour lines highlight the necrotic center of each lesion. Black scale bar: 5mm. (c) Average RIF concentration in plasma, uninvolved lung tissue, and lesions in one subject at steady state. The samples were collected 26h after the last of 180 RIF doses was administered. Means +/− s.d. of 3 to 5 lung pieces or distinct lesions are shown.