TABLE 3.
Biophysical properties of treponemal Tp0751 orthologs
| Tp0751 treponemal orthologa | No. of amino acids (full length/signal sequence truncated) | Molecular size (kDa) (full length/signal sequence truncated) | pI (full length/signal sequence truncated) | % Identity (L126-Y224/M1-P237)b | Signal sequence prediction (SpI or SpII)c |
|---|---|---|---|---|---|
| T. paraluiscuniculi (p) | 237/214 | 25.8/23.3 | 7.3/7.0 | 100/99 | SpII (S23-C24) |
| T. phagedenis (strain 4A) (p) | 497 | 56.3 | 5.5 | 47/13 | NS |
| T. phagedenis (strain F0421) (p) | 497 | 56.3 | 5.5 | 47/13 | NS |
| T. vincentii (p) | 477 | 54.5 | 5.0 | 40/12 | NS |
| T. medium (p) | 477 | 54.4 | 5.3 | 41/13 | NS |
| T. pedis (p) | 493 | 56.3 | 6.1 | 32/11 | NS |
| T. denticola (p) | 491 | 56.8 | 5.3 | 34/11 | NS |
| T. lecithinolyticum (p) | 508/494 | 57.0/55.5 | 5.5/5.3 | 30/11 | SpII (A14-C15) |
| T. socranskii (p) | 528 | 59.6 | 5.3 | 26/9 | NS |
| T. saccharophilum (np) | 792 | 89.0 | 4.9 | 26/8 | NS |
| T. succinifaciens (np) | 495 | 55.6 | 5.4 | 30/14 | NS |
| T. primitia (np) | 501 | 56.5 | 5.0 | 33/12 | NS |
| T. paraluiscuniculi (p) | 237/214 | 25.8/23.3 | 7.3/7.0 | 100/99 | SpII (S23-C24) |
a
p, pathogen; np, nonpathogen.
b
L126-Y224, conserved region of Tp0751; M1-P237, full-length Tp0751.
c
Cleavage sites are indicated in parentheses. NS, not secreted.