Table 1. Recommendation for cessation of anti-inflammatory agents prior to total joint arthroplasty.

Recommendation	Half life	Medication
Continue therapy up to and including the surgery day	1-2 months	Hydroxychloroquine
Hold for at least 1.5 weeks prior to surgery	4.3 days	Etanercept
Hold for 3 weeks prior to surgery	8-10 days	Infliximab
Hold for 1 month prior to surgery	12-14 days	Abatacept; adalimumab; certolizumab; golimumab; tocilizumab
Hold for 6 weeks prior	~2 weeks	Leflunomide
Hold for 2 months prior	21 days	Rituximab
Discontinue 1 week prior to surgery	2-17 h	NSAIDs*
	1-2 h	Allopurinol
	26-32 h	Colchicine
	26-32 h	Probenecid
	5 h	Sulfasalazine
	7.6 h	Azathioprine
	0.7-5.8 h	Methotrexatea*

Adapted from Aggarwal et al. and Rezapoor et al. (26,58). ^a, continue therapy 2 weeks after surgery, for patients with renal dysfunction, hold 2 weeks prior to surgery; *, controversial stop time.