Table 1. MitraClip clinical trials and commercial use with corresponding number of patients (Data as of 11/30/2014, Abbott Vascular).

Study	Population	N* (n=18,505+95 surgery)
EVEREST I (feasibility)	Feasibility patients	55
EVEREST II (pivotal)	Pre-randomized patients	60
EVEREST II (pivotal)	Non-randomized patients (high risk study)	78
EVEREST II (pivotal)	Randomized patients (2:1 clip to surgery)	279: 184 Clip; 95 surgery
REALISM (continued access)	Non-randomized patients	899
Compassionate/emergency use	Non-randomized patients	66
ACCESS Europe phase I	Non-randomized patients	567
ACCESS Europe phase II	Non-randomized patients	286
Commercial use	Commercial patients	16,310

EVEREST II, Endovascular Valve Edge-to-Edge Repair Study II trial; TRAMI, transcatheter mitral valve interventions.