Table 1.
Hepatitis C virus neutralizing antibodies
| Neutralizing antibody | Epitope | Specificity | Escape mutants | Ref. |
| IGH505 | E1 (313-326) linear | Cross-reactive | NA | [27] |
| IGH526 | E1 (313-326) linear | Cross-reactive | NA | [27] |
| H-111 | E1 (192-202) linear | Cross-reactive | NA | [68] |
| 95-2 | E2 (412-423) linear | Cross-reactive | NA | [65] |
| HCV-1 | E2 (412-423) linear | Cross-reactive | NA | [65] |
| HC-1 | E2 (523-540) conformational | Cross-reactive | No escape | [69,125] |
| 3/11 | E2 (412-423) linear | Cross-reactive | N415Y, N415D, N417S, G418D | [75] |
| 3C7 | E2 (396-407) | H strain | NA | [126] |
| AP33 | E2 (412-423) linear | Cross-reactive | N415Y, N415D, N417S, G418D | [75] |
| CBH7 | E2 conformational | Cross-reactive | NA | [74] |
| CBH5 | E2 (523-540) conformational | Cross-reactive | NA | [68,127] |
| CBH2 | E2 (425-447), E2 (523-540) conformational | Cross-reactive | D431G, A439E | [68,125,128] |
| CBH-8C | E2 conformational | Cross-reactive | NA | [129] |
| CBH-8E | E2 conformational | Cross-reactive | NA | [129] |
| CBH-11 | E2 conformational | Cross-reactive | NA | [129] |
| CBH-17 | E2 conformational | Cross-reactive | NA | [129] |
| CBH4B | E2 conformational | Cross-reactive | NA | [129] |
| CBH4D | E2 conformational | Cross-reactive | NA | [129] |
| CBH4G | E2 conformational | Cross-reactive | NA | [129] |
| 9/27 | E2 conformational | H strain | NA | [130] |
| A8 | E2 (523-540) conformational | Cross-reactive | NA | [127] |
| J6.36 | E2 Partially conformational | J6 strain | NA | [131] |
| HC-11 | E2 (425-447) | NA | L438F | [69,125] |
| E2 (523-540) conformational | ||||
| Fab e20 | E2 (523-540) conformational | Cross-reactive | NA | [132] |
| Fab e137 | E2 (412-423) | Cross-reactive | NA | [73] |
| E2 (523-540) conformational | ||||
| 1:7 | E2 (523-540) conformational | Cross-reactive | NA | [127] |
| AR3A | E2 (394-424), E2 (437-447) | Cross-reactive | NA | [76] |
| E2 (523-540) conformational | ||||
| AR3B | E2 (394-424) | Cross-reactive | NA | [76] |
| E2 (437-447) | ||||
| E2(523-540) conformational | ||||
| AR3C | E2 (394-424), E2(437-447) | Cross-reactive | NA | [76] |
| E2 (523-540) conformational | ||||
| AR3D | E2 (394-424), E2 (437-447) | Cross-reactive | NA | [76] |
| E2 (523-540) conformational | ||||
| AP213 | E2 (396-407) partially conformational | Gla strain | NA | [133] |
| H77.39 | E2 (384-520) linear | Cross-reactive | NA | [131] |
| H35 | E2-conformational | Poorly cross-reactive | NA | [134] |
| H48 | E2-conformational | Poorly cross-reactive | NA | [134] |
| 2/69a | E2 (436-443) linear | NA | NA | [135] |
| 9/86a | E2 conformational | NA | NA | [130] |
| 6/1a | E2 (464-471) linear | NA | NA | [130] |
| 9/75 | E2 (524-531) linear | NA | NA | [130] |
| 6/53 | E2 (544-551) linear | NA | NA | [130] |
| 6/16 | E2 (384-391) linear | NA | NA | [130] |
| 1/39 | E2 (432-443) linear | NA | NA | [130] |
| 6/41a | E2 (480-493) linear | NA | NA | [130] |
| 11/20c | E2 (436-447) linear | NA | NA | [130] |
| ALP98 | E2 (644-651) linear | Cross-reactive | NA | [136] |
| ALP1 | E2 (647-658) linear | NA | NA | [136] |
NA: Not available.