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. 2015 Sep 28;6:8403. doi: 10.1038/ncomms9403

Figure 4. Native Sec61 adopts an open conformation in the non-inserting state.

Figure 4

(a) Conformation of native Sec61 in the non-inserting state. The N- and C-terminal halves of Sec61α (green and blue, respectively), Sec61β (yellow) and Sec61γ (orange) are depicted. In the views perpendicular to the membrane the asterisks mark the two TMHs forming the lateral gate. In the views from the cytosol, TMH10 of Sec61α is annotated. (b) Superposition of native (grey) and solubilized Sec61 (coloured as in a; PDBs 3J7Q (ref. 8)) in the non-inserting state. Red arrows indicate the motions of TMHs in the N-terminal half of Sec61α and Sec61β linking both conformations. (c) Conformations of native Sec61 in the non-inserting state (grey) and solubilized SecYE mimicking the inserting state (coloured as in a; PDB 3MP7 (ref. 3)).