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. 2015 Sep 29;6:8393. doi: 10.1038/ncomms9393

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(a) Peri- and (b) cytoplasmic views of GlpT in OF_a, OF_b, IF_b and IF_a states. The dashed lines approximately represent the axis/plane of twofold pseudosymmetry. TM helices H1/H7 and H5/H11 are coloured red and blue, respectively. (c) Interhelical angle of H5/H11 helices plotted against that of H1/H7 helices. Here <A,B, in which ω is the roll axis of the helix (obtained from principal axis component analysis based on C^α atoms). <H1,H7> and <H5,H11> approximately represent the global conformational changes leading to the opening/closing of the peri- and cytoplasmic sides, respectively. The error bars represent the s.d. (see Analysis techniques in Methods section). (d) PMF in terms of (QPC₁,QPC₂), that is, the first two principal components of the vector parts of the {Q} quaternions. The pathways shown in c and d are based on the (unweighted) averaged centres of the 150 images (also see Fig. 1e).

Inline graphic — (a) Peri- and (b) cytoplasmic views of GlpT in OF_a, OF_b, IF_b and IF_a states. The dashed lines approximately represent the axis/plane of twofold pseudosymmetry. TM helices H1/H7 and H5/H11 are coloured red and blue, respectively. (c) Interhelical angle of H5/H11 helices plotted against that of H1/H7 helices. Here <A,B, in which ω is the roll axis of the helix (obtained from principal axis component analysis based on C^α atoms). <H1,H7> and <H5,H11> approximately represent the global conformational changes leading to the opening/closing of the peri- and cytoplasmic sides, respectively. The error bars represent the s.d. (see Analysis techniques in Methods section). (d) PMF in terms of (QPC₁,QPC₂), that is, the first two principal components of the vector parts of the {Q} quaternions. The pathways shown in c and d are based on the (unweighted) averaged centres of the 150 images (also see Fig. 1e).