Table 3.
Data of Dry Matter Intake (DMI), milk production, milk composition as well as metabolites, cytokines and APPs in the serum of dairy cows with (n = 6) and without lameness (LAM) during the periparturient period.
| Group 1 | Effect,2 P-Value | |||||
|---|---|---|---|---|---|---|
| Item | LAM | CON | SEM | Hs | Wk | Hs × Wk |
| DMI 3 (kg/d) | 17.19 | 18.64 | 0.58 | 0.13 | <0.01 | <0.01 |
| Milk production 4 (kg/d) | 36.79 | 42.16 | 2.58 | 0.05 | <0.01 | 0.09 |
| Milk composition 5 (g/kg, unless otherwise stated) | ||||||
| Fat | 3.15 | 3.90 | 0.14 | <0.01 | 0.04 | 0.35 |
| Protein | 2.86 | 2.87 | 0.06 | 0.94 | <0.01 | 0.45 |
| Fat-to-protein ratio | 1.10 | 1.38 | 0.09 | 0.05 | 0.17 | 0.63 |
| Lactose | 4.55 | 4.56 | 0.04 | 0.84 | 0.02 | 0.47 |
| SCC (103 cells/mL) | 57.90 | 30.0 | 5.37 | <0.01 | 0.10 | 0.28 |
| Milk urea N (mg/dL) | 15.47 | 15.56 | 0.96 | 0.95 | 0.01 | <0.01 |
| TS | 12.00 | 12.19 | 0.25 | 0.30 | 0.03 | 0.50 |
| Serum parameters 6 | ||||||
| Lactate (μmol/L) | 4550.67 | 2254.08 | 399.21 | <0.01 | 0.20 | 0.62 |
| NEFA (mmol/L) | 261.85 | 397.16 | 78.05 | 0.26 | <0.01 | 0.92 |
| BHBA (μmol/L) | 509.38 | 595.84 | 66.49 | 0.39 | <0.01 | 0.35 |
| IL-1 (pg/mL) | 287.98 | 296.66 | 4.58 | 0.21 | <0.01 | 0.02 |
| IL-6 (pg/mL) | 175.78 | 26.67 | 35.51 | 0.02 | 0.21 | 0.34 |
| TNF (ng/mL) | 0.40 | 0.19 | 0.08 | 0.09 | <0.01 | 0.03 |
| Haptoglobin (mg/mL) | 0.21 | 0.15 | 0.03 | 0.14 | 0.24 | 0.03 |
| SAA (ug/mL) | 19628 | 8548.38 | 2440.73 | <0.01 | 0.02 | 0.39 |
1 CON = cows without lameness (health control); LAM = cows with lameness. 2 Effect of health status (Hs), sampling week (Wk), and health status by sampling week interaction (Hs × Wk). 3 DMI was calculated from week −8 to +8 relative to parturition. 4 Milk production was calculated from week +1 to +8 relative to parturition. 5 Milk compositions were determined on week +2, +3, +5, +7 relative to parturition. 6 Serum parameters were calculated from week −8, −4, disease and +4 relative to parturition.