Table 4.
8 Week before Parturition | 4 Week before Parturition | LAM Diagnosis Week 1 | |||||||
---|---|---|---|---|---|---|---|---|---|
Item | CON | LAM | P-value | CON | LAM | P-value | CON | LAM | P-value |
DMI (kg/d) | 14.91 ± 0.90 | 16.49 ± 1.01 | 0.28 | 15.90 ± 0.14 | 15.95 ± 0.67 | 0.96 | 20.26 ± 0.89 | 13.25 ± 1.11 | <0.01 |
Milk production (kg/d) | 43.01 ± 1.62 | 29.78 ± 4.01 | 0.01 | ||||||
Milk composition (g/kg, unless otherwise stated) | |||||||||
Fat | 5.08 ± 0.45 | 3.39 ± 0.41 | 0.02 | ||||||
Protein | 3.00 ± 0.10 | 2.85 ± 0.07 | 0.25 | ||||||
Fat-to-Protein ratio | 1.69 ± 0.12 | 1.20 ± 0.15 | 0.03 | ||||||
Lactose | 4.54 ± 0.05 | 4.43 ± 0.13 | 0.42 | ||||||
SCC (103 cells/mL) | 28.33 ± 5.63 | 66.50 ± 15.31 | 0.03 | ||||||
Milk urea N (mg/dL) | 15.39 ± 0.76 | 14.08 ± 1.22 | 0.37 | ||||||
TS | 12.21 ± 0.31 | 13.47 ± 1.21 | 0.37 | ||||||
Serum parameters | |||||||||
Lactate (μmol/L) | 2455.49 ± 348.63 | 5427.91 ± 1095.28 | 0.04 | 2162.31 ± 184.52 | 4232.93 ± 748.08 | 0.04 | 2,227.61 ± 320.68 | 4,760.82 ± 519.38 | <0.01 |
NEFA (mmol/L) | 140.79 ± 32.77 | 107.34 ± 20.88 | 0.41 | 193.97 ± 47.17 | 82.89 ± 6.96 | 0.07 | 756.51 ± 232.01 | 594.63 ± 206.20 | 0.61 |
BHBA (μmol/L) | 351.93 ± 37.71 | 374.48 ± 31.14 | 0.65 | 311.98 ± 18.50 | 366.32 ± 17.12 | 0.06 | 826.91 ± 151.50 | 586.69 ± 93.88 | 0.23 |
IL-1 (pg/mL) | 316.79 ± 6.04 | 293.92 ± 9.23 | 0.07 | 320.96 ± 1.59 | 302.73 ± 7.26 | 0.05 | 277.13 ± 5.42 | 281.30 ± 7.70 | 0.67 |
IL-6 (pg/mL) | 19.23 ± 5.67 | 85.37 ± 52.96 | 0.30 | 48.24 ± 17.51 | 250.81 ± 87.08 | 0.03 | 23.17 ± 5.18 | 113.41 ± 21.96 | 0.02 |
TNF (ng/mL) | 0.34 ± 0.03 | 0.39 ± 0.12 | 0.80 | 0.27 ± 0.05 | 0.51 ± 0.11 | 0.10 | 0.06 ± 0.03 | 0.48 ± 0.13 | 0.02 |
Haptoglobin (mg/mL) | 0.19 ± 0.03 | 0.17 ± 0.01 | 0.54 | 0.15 ± 0.01 | 0.20 ± 0.02 | 0.05 | 0.12 ± 0.01 | 0.36 ± 0.10 | 0.05 |
SAA (ug/mL) | 8447.67 ± 3373.28 | 19799.92 ± 4373.22 | 0.07 | 3461.25 ± 341.92 | 9732.1 ± 2625.98 | 0.03 | 10401 ± 1722.57 | 29300.17 ± 8108.13 | 0.05 |
1 Cows were diagnosed with lameness (n = 6) ranging from week +1 to +3. CON = cows without lameness (healthy control); LAM = cows with lameness.