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. 2015 Sep 30;6:8419. doi: 10.1038/ncomms9419

Figure 7. Aberrant accumulation of PRMT5 and KLF4 correlate with poor prognosis of breast cancer.

Figure 7

(a,b). Accumulated KLF4 and PRMT5 protein was observed in human breast cancer tissue by IHC in comparison with adjacent normal breast tissue. (a) tissue arrays of 64 human breast cancer specimens with adjacent normal breast tissue were subjected to immunohistochemistry with anti-KLF4 and anti-PRMT5 antibodies and visualized by DAB staining. (b) Summary of (a). (c,d). Severe accumulation of KLF4 and PRMT5 protein in triple negative breast cancer tissue was detected in comparison with HER2 and ER/PR positive type breast tumors. Tissue arrays of 193 human invasive breast cancer specimens, including 80 HER2+, 45 ER/PR+ and 68 triple negative breast cancer tissues, were detected. The represented staining were shown in (c) and summarized in (d). The results were presented as mean values±s.e.m. *P<0.01, *P<0.05 using Student's t-test. Scale bar, 50 μm.