Figure 2.

CpG islands and Akirin2 mediated transcriptional control. CpG island promoters are commonly found among genes which are transiently induced and also in the genes that are induced by a broad range of stimuli (such as Tnf, Cxcl1, etc.). These genes are proposed to have open chromatin and are Akirin2 independent which do not require chromatin remodeling for their transcription. In contrast, low CpG island promoters often require active nucleosome remodeling by SWI/SNF remodeling complexes following stimulation (such as Il6, Il12b, etc.). These low CpG island promoters have restricted chromatin access and consist of Akirin2 dependent genes requiring Akirin2 mediated recruitment of SWI/SNF remodeling complex for facilitating the gene transcription. These CpG island promoters can activate transcription factors, such as NF-κB upon activation by a broad range of stimuli and are frequently regulated by the stimulus specificity of a transcriptional response.