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SUMO-1 marks lysosomes in α-synuclein inclusion body bearing cells in multiple system atrophy and rotenone rat α-synucleinopathy model tissue. Immunofluorescence triple labelling for SUMO-1, the lysosome marker, CatD, and α-synuclein reveals frequent colocalization of SUMO-1 with lysosomes (arrowheads) in close proximity to α-synuclein inclusion bodies (arrows) [24].
