Table 1.
Bivariate associations of AOSI score with demographic and laboratory variables for the EARLI study population
| Total 12-month AOSI score (N = 44) |
CHARM (N = 44) | Subset also with 450 K (N = 30) | ||
|---|---|---|---|---|
| Variable | Mean (SD) | P-value | N (%) | N (%) |
| Age quartile | ||||
| 27–32.7 | 6.5 (4.5) | 12 (27.3) | 9 (30) | |
| 32.8–36 | 5 (5.8) | 10 (22.7) | 7 (23.3) | |
| 36.1–40.3 | 5.7 (4) | 11 (25) | 10 (33.3) | |
| 40.2–51.2 | 5.4 (3.7) | 0.88 | 11 (25) | 4 (13.3) |
| Race, ethnicity | ||||
| Black, Hispanic | 7 (NA) | 1 (2.3) | 1 (3.3) | |
| Black, non-Hispanic | 4.7 (2.5) | 3 (6.8) | 2 (6.7) | |
| Other, Hispanic | 7.5 (0.7) | 2 (4.5) | 1 (3.3) | |
| Other, non- Hispanic | 5 (4.2) | 2 (4.5) | 1 (3.3) | |
| White, Hispanic | 3 (NA) | 1 (2.3) | 1 (3.3) | |
| White, non- Hispanic | 5.4 (4.5) | 32 (72.7) | 22 (73.3) | |
| White, other | 12 (8.5) | 0.63 | 2 (4.5) | 2 (6.7) |
| Missing | 4 (NA) | 1 (2.3) | - | |
| Study site | ||||
| Drexel | 8.5 (5.5) | 14 (31.8) | 10 (33.3) | |
| Johns Hopkins | 3.6 (2.8) | 15 (34.1) | 9 (30) | |
| Kaiser | 4.3 (3.8) | 7 (15.9) | 6 (20) | |
| UC Davis | 5.9 (2.4) | 0.014 | 8 (18.2) | 5 (16.7) |
| Paternity status | ||||
| Proband and sibling | 5.6 (4.6) | 37 (84.1) | 24 (80) | |
| Sibling only | 5.9 (3.2) | 0.91 | 7 (15.9) | 6 (20) |
| Paternal education | ||||
| High school graduate or less | 5.5 (2.1) | 8 (18.2) | 5 (16.7) | |
| Some college | 8.2 (6.2) | 9 (20.5) | 6 (20) | |
| Bachelor's degree | 4.8 (3.8) | 13 (29.5) | 9 (30) | |
| Graduate degree | 4.9 (4.3) | 0.27 | 14 (31.8) | 10 (33.3) |
| Annual income | ||||
| < US$49,999 | 5.6 (2.3) | 9 (20.5) | 6 (20) | |
| $50,000–$74,999 | 7.6 (7.2) | 5 (11.4) | 4 (13.3) | |
| $75,000–$99,999 | 5.5 (4.8) | 13 (29.5) | 10 (33.3) | |
| >=$100,000 | 5.4 (4.2) | 0.79 | 17 (38.6) | 10 (33.3) |
| Shear date | ||||
| 1 | 5.9 (4.5) | 9 (20.5) | - | |
| 2 | 5.1 (4.4) | 18 (40.9) | - | |
| 3 | 6.2 (4.4) | 0.77 | 17 (38.6) | - |
| Shear machine (HS) | ||||
| 2 | 5.6 (5.2) | 19 (43.2) | - | |
| 3 | 5.9 (3.8) | 22 (50) | - | |
| 4 | 4.7 (4.2) | 0.90 | 3 (6.8) | - |
| CHARM gel | ||||
| 1 | 0 (NA) | 1 (2.3) | - | |
| 2 | 5.2 (3.2) | 4 (9.1) | - | |
| 3 | 8 (5.1) | 4 (9.1) | - | |
| 4 | 7 (7.4) | 4 (9.1) | - | |
| 5 | 3.3 (1.5) | 3 (6.8) | - | |
| 6 | 2 (0) | 2 (4.5) | - | |
| 7 | 4.2 (3.9) | 4 (9.1) | - | |
| 8 | 8 (4) | 3 (6.8) | - | |
| 9 | 4.5 (3.5) | 2 (4.5) | - | |
| 10 | 8.3 (8.5) | 3 (6.8) | - | |
| 11 | 7.2 (4.9) | 4 (9.1) | - | |
| 12 | 3 (1) | 3 (6.8) | - | |
| 13 | 7.8 (2.2) | 4 (9.1) | - | |
| 14 | 3.7 (1.5) | 0.65 | 3 (6.8) | - |
| Gel location | ||||
| Bottom middle | 2 (NA) | 1 (2.3) | - | |
| Bottom left | 4.6 (4.5) | 12 (27.3) | - | |
| Bottom right | 6.9 (2.9) | 8 (18.2) | - | |
| Top left | 5.8 (5.6) | 12 (27.3) | - | |
| Top right | 6.2 (3.8) | 0.71 | 11 (25) | - |
| Hybridization date | ||||
| 1 | 5 (4.5) | 20 (45.5) | 20 (66.7) | |
| 2 | 6.2 (4.3) | 0.39 | 24 (54.5) | 8 (26.7) |
| 3 | - | - | 2 (6.7) | |
NA, not applicable.