Table 3.
Selected eQTL analysis results (P < 0.05) of genes (P-valueGENE < 0.05) in normal oesophageal and stomach tissues
| Shanxi normal esophagus (n = 100) |
GTEx normal esophagus mucosa (n = 95)b |
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|---|---|---|---|---|---|---|---|---|---|
| Gene | Top-ranked SNP | OR (95% CI) | U133A mRNA probe | Major/minor | rhoa | P-value | Ref/Alt | Direction | P-value |
| EED | rs10898459 | 0.88 (0.81–0.96) | 209572_s_at | C/T | −0.22 | 0.029 | T/C | + | 0.060 |
|
Shanxi normal stomach (n = 90) |
GTEx normal stomach (n = 76)b |
||||||||
| U133A mRNA probe | Major/minor | rhoa | P-value | Ref/Alt | Direction | P-value | |||
| ASH1L | rs12724079 | 0.84 (0.75–0.94) | 218554_s_at | T/C | 0.35 | 0.0006 | T/C | + | 0.800 |
|
Shanxi normal cardia stomach (n = 34) |
GTEx normal stomach (n = 76)b |
||||||||
| U133A mRNA probe | Major/minor | rhoa | P-value | Ref/Alt | Direction | P-value | |||
| DICER1 | rs7157322 | 1.17 (1.05–1.30) | 206061_s_at | A/C | −0.42 | 0.014 | A/C | ± | 0.200 |
| ASH1L | rs8179271 | 0.85 (0.75–0.96) | 218554_s_at | A/G | −0.35 | 0.045 | No SNP | No SNP | No SNP |
|
Shanxi normal non-cardia stomach (n = 56) |
GTEx normal stomach (n = 76)b |
||||||||
| U133A mRNA probe | Major/minor | rhoa | P-value | Ref/Alt | Direction | P-value | |||
| PPP1CA | rs1790733 | 1.16 (1.01–1.33) | 200846_s_at | T/C | −0.41 | 0.002 | A/G | ± | 0.400 |
Abbreviations: eQTL, expression quantitative trait loci; Ref/Alt, reference/alternative allele.
a Statistical significance for correlation (rho) was determined using nonparametric Spearman's rank test; Direction is based on minor allele.
b GTEx Portal [http://www.gtexportal.org/home/]; Direction is based on alternative allele.; Symbols: +, positive influence; ±, no change.