Table 4.
Cross-reactivity of Vaccinated Ferret Serum to Heterologous H7 Avian Influenza Viruses in an HI Assay
| Vaccine Group (Dose, µg) by Ferret ID | HI-Titer by Virus Straina |
||||
|---|---|---|---|---|---|
| rg-A/Netherlands/219/03 (H7N7) | rg-A/Canada/rv444/04 (H7N3) | A/Equine/Prague/56 (H7N7) | A/Ruddy Turnstone/NJ/65/85 (H7N3) | A/Anhui/1/2013 (H7N9)b | |
| MF59 (3.75) | |||||
| ARC1 | 5 | 5 | 5 | 5 | 40 |
| ARC2 | 5 | 5 | 5 | 5 | 40 |
| ARC3 | 5 | 5 | 20 | 5 | 80 |
| ARC4 | 5 | 5 | 5 | 5 | 5 |
| ARC5 | 5 | 5 | 20 | 40 | 320 |
| ARC6 | 5 | 5 | 5 | 5 | 40 |
| GMT (95% CI) | 5 (5) | 5 (5) | 7.9 (3.7–16.83) | 7.1 (2.9–17.2) | 44.9 (10.9–184.3) |
| AS03 (3.75) | |||||
| ARC7 | 5 | 5 | 40 | 40 | 320 |
| ARC8 | 5 | 5 | 5 | 40 | 160 |
| ARC9 | 40 | 40 | 80 | 160 | 2560 |
| ARC10 | 5 | 5 | 20 | 40 | 320 |
| ARC12 | 80 | 40 | 320 | 320 | 40 960 |
| ARC13 | 40 | 20 | 40 | 80 | 320 |
| GMT (95% CI) | 15.9 (4.1–61.5) | 12.6 (4.2–37.7) | 40 (9.4–171.4) | 80 (31.9–200.8) | 905.1 (100.8–8125) |
| MF59 (15) | |||||
| ARC23 | 20 | 5 | 5 | 40 | 320 |
| ARC24 | 40 | 20 | 80 | 80 | 20 480 |
| ARC25 | 40 | 5 | 5 | 10 | 5 |
| ARC26 | 20 | 20 | 20 | 40 | 640 |
| ARC27 | 40 | 5 | 5 | 40 | 160 |
| ARC28 | 40 | 10 | 20 | 40 | 320 |
| GMT (95% CI) | 31.7 (21.8–46.2) | 8.9 (4.3–18.2) | 12.6 (3.8–41.3) | 35.6 (17.4–72.9) | 320.0 (19.4–5256) |
| AS03 (15) | |||||
| ARC29 | 5 | 5 | 5 | 5 | 160 |
| ARC30 | 160 | 80 | 160 | 80 | 2560 |
| ARC31 | 5 | 5 | 10 | 20 | 5120 |
| ARC32 | 5 | 5 | 20 | 20 | 640 |
| ARC34 | 5 | 5 | 5 | 40 | 320 |
| ARC35 | 5 | 5 | 160 | 40 | 2560 |
| GMT (95% CI) | 8.9 (2.0–39.4) | 7.9 (2.5–26.0) | 22.4 (4.2–121.1) | 25.2 (9.3–68.1) | 1016 (243.0–4248) |
Abbreviations: CI, confidence interval; GMT, geometric mean titer; HI, hemagglutination inhibition.
a Titers less than the starting dilution of 1:20 were arbitrarily set at 5.
b Homologous titers.