Figure 3. Potency of different odorants on Olfr73 and Olfr74 wildtype and mutant receptor activation.

Schematic representation of the potency of jasmone, rose oxide and nootkatone in activating Olfr73, Olfr74 wildtype receptors and the corresponding point mutants in positions 113, 208 and 260. Specific amino acid changes are highlighted with grey and green shaded circles. Roman numbers indicate numbers of trans-membrane helices. The potency of OR activation is illustrated with a rainbow color spectrum ranging from blue corresponding to a low efficacy values (EC₅₀ > 100 μM) to red corresponding to high efficacy values (EC₅₀ = 10 μM). No response: no receptor activation detectable in the reporter assay. Corresponding dose response curves are shown in Supplementary Fig. 3 and Supplementary Fig. 4.