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. 2015 Oct 9;5:14917. doi: 10.1038/srep14917

Figure 6. In vivo PCB126 exposure alters neutrophil chemotaxis and ROS production elicited by fMLP.

Figure 6

Chemotaxis (a) and ROS production evoked by fMLP (b), LPS (c), or PMA (d) in neutrophils collected from male Wistar rats exposed to vehicle or PCB126 (10 μg/kg once a day during 15 days). Five hours after the last exposures, blood neutrophils were isolated from blood and chemotaxis (a) was evaluated using a Boyden Chamber in basal or fMLP (100 nmol/L) conditions. ROS production induced by fMLP (100 nmol/L) (b), LPS (5 μg/mL) (c), or PMA (100 ng/mL) (d) were measured by flow cytometry. Data (n = 8 for each group) were analysed by one-way ANOVA followed by Tukey’s test. *P < 0.05,**P < 0.01 and ***P < 0.001 vs. values in vehicle treated rats; #P < 0.05, ###P < 0.001 vs. vehicle fMLP; &P < 0.05 vs. PCB126 10 μg/kg in basal condition.