Table 2. Recurrent mutations in JAK–STAT and PLCG1.

Gene	ID	Consequence	Amino-acid change	Chr	Position	Ref	Alt	Somatic acquisition confirmed*
JAK1	SS87	Missense	p.Y654F	1	65,312,358	T	A	Yes
	SS29	Missense	p.L710V	1	65,310,560	G	C	Yes
JAK3	SS33	Missense	p.S989I	19	17,942,049	C	A	Yes
	SS47	Missense	p.Y1023H	19	17,941,341	A	G	Yes
STAT3	SS29	Missense	p.I498V	17	40,476,837	T	C	Yes
	SS37	Missense	p.Y640F	17	40,474,482	T	A	Yes
STAT5B	SS55	Missense	p.N642H	17	40,359,729	T	G	Yes
	SS86	Missense	p.N642H	17	40,359,729	T	G	Yes
PLCG1	SS26	Missense	p.S345F	20	39,792,584	C	T	Yes
	SS31	Missense	p.S345F	20	39,792,584	C	T	Yes
	SS84	Missense	p.S520F	20	39,794,139	C	T	Yes
	SSG01	Missense	p.R1158H	20	39,802,370	G	A	Yes
	SS86	Deletion	p.VYEEDM1161V	20	39,802,378	GTGTATGAGGAAGACA	G	Yes
	SS9	Missense	p.E1163K	20	39,802,384	G	A	Yes

^*NGS and/or Sanger conformation of somatic status in cases where normal tissue was available.