Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 9;5:15009. doi: 10.1038/srep15009

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(a) Three-weeks after adolescent antidepressant exposure (postnatal day [PD]-75), FLX-pretreated mice displayed enhanced sensitivity to 5 and 10 mg/kg cocaine, when compared to vehicle (VEH)-pretreated mice (n = 8–11 per group; *p < 0.05). (b) Conversely, adult FLX-pretreatment did not influence preference for the cocaine-paired side, three-weeks after antidepressant exposure (PD 105; n = 7–10 per group; p > 0.05). Regardless of age, VEH-and FLX-pretreated mice displayed reliable conditioning to cocaine (^αp < 0.05). *Within cocaine group comparison (p < 0.05). ^αSignificantly different when compared to age-matched controls conditioned to saline (p < 0.05).