Figure 3. Transfer of primed CD8⁺ T cells prolongs survival of N. caninum-challenged ScCr mice.

Survival of ScCr mice infected with 5 × 10⁵ NcT 16 h upon the adoptive transfer of CD8⁺ T cells obtained from the spleen of ScSn mice injected with PBS (Unprimed CD8) or infected with 1 × 10⁷ NcT (Primed CD8). Survival of similarly infected ScCr and ScSn non-transferred controls are also shown, as indicated. Statistical difference between the two transferred groups was calculated with the log-Rank test (n = 6, control; n = 9, infected) and is indicated. Statistical differences between the unprimed CD8 and primed CD8 groups and ScCr controls were of P = 0.0061 and P < 0.0001, respectively. Data correspond to pooled results of two independent experiments.