Table 1.
Characteristics of the dogs and their invasive mammary carcinomas
| Parameters | Data |
|---|---|
| n (%) | |
| Total | 150 (100) |
| Age in yrs | Median 11 yrs, Range [5.1–16.3 yrs] |
| 5.1–10.9 yrs | 73 (48.7) |
| ≥11 yrs | 77 (51.3) |
| Tumor size | |
| < 2 cm | 53 (36.5) |
| ≥ 2 cm | 92 (63.5) |
| Histological type | |
| Squamous cell carcinoma | 6 (4) |
| Simple carcinoma: Anaplastic | 6 (4) |
| Complex carcinoma | 11 (7.3) |
| Simple carcinoma: Solid | 40 (26.7) |
| Simple carcinoma: Tubulopapillary | 87 (58) |
| Histological grade (Elston & Ellis) | |
| Grade I | 19 (12.6) |
| Grade II | 58 (38.7) |
| Grade III | 73 (48.7) |
| Lymph node status | |
| Positive (N1) | 32 (21.3) |
| Negative (N0) | 19 (12.7) |
| Unknown (NX) | 99 (66) |
| ER expression | |
| Positive (≥ 10 %) | 35 (23.3) |
| Negative (< 10 %) | 115 (76.7) |
| PR expression | |
| Positive (≥ 10 %) | 20 (13.3) |
| Negative (< 10 %) | 130 (86.7) |
| HER2 | |
| Score 0 | 85 (56.7) |
| Score 1+ | 50 (33.3) |
| Score 2+ | 15 (10) |
| Score 3+ | 0 |
| CK5/6 | |
| Positive (≥ 10 %) | 89 (59.3) |
| Negative (< 10 %) | 61 (40.7) |
| EGFR | |
| Positive (≥ 10 %) | 72 (48) |
| Negative (< 10 %) | 78 (52) |
| Immunophenotype | |
| Luminal-A | 17 (11.3) |
| Luminal-B | 30 (20) |
| Triple-negative basal like | 70 (46.7) |
| Triple-negative non basal like | 33 (22) |
| IGF1R expression | |
| Score 0–1+ | 34 (22.7) |
| Score 2+ | 54 (36) |
| Score 3+ | 62 (41.3) |
| Survival Time in days | Median 331 days, Range [2–2608] |
yrs years, ER Estrogen Receptor, PR Progesterone Receptor, HER2 Epidermal Growth Factor Receptor 2, CK5/6 Cytokeratin 5/6, EGFR Epidermal Growth Factor Receptor, IGF1R Insulin-like growth factor type 1 receptor