Table 2.
Significant associations between IGF1R expression and clinicopathological features of the 150 canine mammary carcinomas
| Parameters | Fisher’s exact test | IGF1R score 2+ | IGF1R score 3+ | ||||
|---|---|---|---|---|---|---|---|
| p-value | OR | 95 % CI | p-value | OR | 95 % CI | ||
| Histological grade | <0.001 | ||||||
| Grade I or II | - | 1.00 | - | - | 1.00 | - | |
| Grade III | 0.007 | 3.86 | 1.49–10.99 | <0.001 | 6.54 | 2.57–18.53 | |
| LVI | 0.006 | ||||||
| Absent | - | 1.00 | - | - | 1.00 | - | |
| Present | 0.87 | 1.08 | 0.44–2.68 | 0.01 | 3.11 | 1.32–7.62 | |
| ER expression | 0.004 | ||||||
| Positive (≥ 10 %) | - | 1.00 | - | - | 1.00 | - | |
| Negative (< 10 %) | 0.003 | 4.54 | 1.69–13.01 | 0.01 | 3.29 | 1.32–8.46 | |
| PR expression | 0.04 | ||||||
| Positive (≥ 10 %) | - | 1.00 | - | - | 1.00 | - | |
| Negative (< 10 %) | 0.07 | 2.88 | 0.93–9.47 | 0.02 | 4.10 | 1.29–14.54 | |
| Immunophenotype | 0.03 | ||||||
| Luminal | - | 1.00 | - | - | 1.00 | - | |
| Triple Negative | 0.02 | 2.86 | 1.16–7.20 | 0.02 | 2.88 | 1.20–7.04 | |
IGF1R score 0–1+ is considered as the reference for each parameter
IGF1R Insulin-like growth factor type 1 receptor, LVI Lymphovascular Invasion, ER Estrogen Receptor, PR Progesterone Receptor, OR Odds Ratio, 95 % CI 95 % Confidence Interval