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JNJ-61186372 binds simultaneously to both c-MET and EGFR monomer. c-MET-Fc-His was captured onto a HTG sensor chip. JNJ-61186372 (A) or inert arm × c-MET (B) was co-injected with serially diluted EGFR monomer over the captured c-MET-Fc-His molecule. The sensorgrams are shown per EGFR concentration in red (100 nm), aqua blue (25 nm), blue (6.25 nm), green (1.56 nm), pink (0.39 nm), and orange (0 nm).
