TABLE 1.
Genotypes of EGFR and c-MET in cancer cell lines
The following abbreviations were used: ACA, adenocarcinoma; del, deletion mutant; BAC, bronchioalveoloar carcinoma; MEC, mucoepidermoid carcinoma; ND, not determined; SCC, squamous cell carcinoma; UNK, unknown, WT, wild type; Y, yes; N, no.
| Cell line | Origin | EGFR |
c-MET |
||
|---|---|---|---|---|---|
| Genotype | Amplified (copies/cell) | Genotype | Amplified (copies/cell) | ||
| H292 | Lung MEC | WT | N | WT | N |
| SKMES-1 | Lung SCC | WT | N | WT | N |
| HCC827 | Lung ACA | del (E746, A750) | Y (19) | WT | N |
| H1975 | Lung ACA | L858R, T790M | N | WT | N |
| H3255 | Lung ACA | L858R | Y (12) | WT | N |
| H1650 | Lung BAC | del (E746, A750) | Y (4) | WT | N |
| HCC4006 | Lung ACA | del (L747, S752) | Y (5) | WT | N |
| HCC2935 | Lung ACA | del (E746, A750) | N | WT | N |
| H820a | Lung ACA | del (E746, A750), | UNKa | WT | Y (4–6) |
| T790M | |||||
| H1993a | Lung ACA | WT | UNKa | WT | Y (UNKa) |
| SNU-5 | Stomach ACA | WT | N | WT | Y (9) |
a Not in Cancer Cell Line Encyclopedia.